Genomics and Bioinformatics

Genomics and Bioinformatics melds the disciplines of statistics, computer science and life sciences and involves both computationally-oriented informaticians and wet-bench oriented genomicists.

Personnel

The biology of RNA regulatory networks in plant development and communication. Through the use of transcriptomics sequencing data and computational biology, our goal is to discover RNA regulatory networks and their roles in plant cell development, and response to pathogens, enviromental stresses and sybmbionts. We study the RNA regulatory networks…

Research in Dr. Bar-Peled’s group aims to understand, at the molecular level, the roles of complex glycans in living organisms. We are interested in the roles of cell surface glycans (“sugar coated polymers”) in cell-cell recognition, pathogenicity, and communication between micro-organisms and their plant or animal hosts. In addition, we are…

Plant genome structure and evolution, especially the nature of rearrangements and the contributions of transposable elements. The relationship between genome structure/evolution and gene function. Genetic diversity and its use in under-utilized crops of the developing world. The rapid evolution of complex disease resistance loci in plants.…

Genomes only make sense in the light of evolution, so we use a combined evolutionary and bioinformatics approach to study the parts of genomes people know least about: centromeres, repetitive and other noncoding DNA. We are also interested in the invisible world of microbes. By studying the genomes of wine yeast we hope to answer fundamental…

Our primary focus is plant evolutionary genetics and genomics. More specifically, we're studying the genetic basis of evolutionary divergence within the sunflower family (i.e., the Compositae or the Asteraceae). We also maintain an interest in the ecological and evolutionary impact of transgene escape from genetically modified crops into their…

The Dawe lab studies genome structure and cell division in maize, focusing on the biology of centromeres.  Students and postdocs work at all levels of genetics, including traditional genetics, cytogenetics, molecular genetics, epigenetics and bioinformatics. We also work intensively with microscopes to visualize cell division using fixed and…

The research in my lab is targeted on enhancing our understanding of the organization of grass genomes, in particular wheat, millets and switchgrass, a biofuel crop. This is done through genetic and genomic analyses in the target species themselves, as well as through comparative analyses between crop and sequenced model genomes.

My research employs genomic, phylogenetic and experimental analyses to investigate the genetic and ecology processes that influence diversification. Specific interests include the molecular genetics of diversification including speciation; the molecular basis of adaptation; the evolution of genome structure; genomic processes influencing gene…

Chromatin structure and function; Epigenetics; Eukaryotic genome stability; Histone H1

We are interested in understanding epigenetic and chromatin-based mechanisms that contribute to eukaryotic genome function, genome organization, and genome stability. In the nucleus, chromosomal DNA is packaged with histone and non-histone proteins…

My current research interests are in the broad areas of bioinformatics and plant evolutionary/ecological genetics. We are studying the genetics, evolution, and ecology, of the insect-eating pitcher plants (Sarracenia species). Most of my bioinformatics work is in collaboration with Liming Cai of the Computer Science Department to develop…

My lab studies intrinsic genetic properties that make plants different from other organisms and from one another. In particular, selected plants have become crops because of unique attributes that also make them valuable as botanical models. Crop genetics thus offers the opportunity to increase basic scientific knowledge and apply it to…

Population Epigenomics and Mechanisms of Epigenetic Inheritance

We are interested in determining how phenotypic plasticity and diversity are driven by natural and spontaneous epigenetic variation. Recent advances in genomic technologies are enabling acquisition of sequence-level data at an unprecedented rate and resolution. As a result…

phenylpropanoid metabolism growth-defense tradeoff gene family evolution and functional diservification functional genomics metabolite engineering

The current research in my lab is directed to understand the establishment and maintenance of histone modifications in plants, their roles in regulating gene expression and development, and how they have contributed to the evolution of gene and genome functions. We use Arabidopsis and rice as model systems and employ a wide range of approaches…